Considering the conference they were in for a vast majority of those 25 years, no. The only way Northridge would ever have a chance at winning the SWBL was if the 2 or 3 perennially decent teams in their division happened to be bad at the same time.
I think Northridge's problem is that it's impossible to keep talented athletes there. They're bordered by several much larger districts with better....everything... so athletes likely just transfer putting them in a perpetual state of "do more with less".
The only way they were ever going to win a league title was to move to a weaker conference. Which is what happened.
This is a pointless argument to make, but I'd wager if you took this current Northridge team and placed them in the ~2004 SWBL they'd probably be the third best team in their side of the division.
2004 SWBL (Buckeye) would've been:
Dixie
Preble
Carlisle
Madison
Ridge
Waynesville
They also would've had a few crossover games from the SW side:
Brookville
Milton
Eaton
Valley View
Oakwood
Bellbrook
Depending on how their non-con/crossover games fell, they could just as easily be 2-8/3-7 if they were still in the SWBL.