I would say these teams have a chance to win the region:
Lake Catholic, Cardinal Mooney, Poland Seminary, Canton South, Struthers, West Branch
The dark horses are Niles McKinley, Streetsboro and Girard
No one else has a realistic chance
The fact that Jefferson won the region last year was a fluke and required a lot of good luck more than anything else, a lot of very unlikely things happened and the stars alligned allowing them to win the region. Jefferson had everything go their way. Quite a few other teams in the region were better than Jefferson last year, but many of them had injuries and were all banged up, meanwhile Jefferson was relatively healthy. Mind you even if West Branch had their QB at 100% an available to play defense, they still get slaughtered by Glenville just the same.