"Upgrade" - by Blake Crouch
In the very near future, a man unknowing has over thousands of his genes altered, giving him quasi-superhuman abilities of strength, concentration, and memory, and at a steep price. He must find out how, why, and who did it in order to avoid being imprisoned by the government, and to stop more people from becoming affected.
Lots of genetic science and almost-everyday technology. Crouch devilishily ends this one with an anticlimax - a painfully bittersweet scene - and a twist.