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Neale’s team examined DNA markers and data from surveys of sexual behavior filled out by nearly 409,000 UK Biobank participants and about 69,000 customers of 23andMe, the consumer testing service; all were of European ancestry. The UK Biobank survey asked: “Have you ever had sexual intercourse with someone of the same sex?”; the 23andMe survey featured a similar question. The team found five genetic markers significantly associated with answering yes to those queries. Two markers were shared by men and women, two were specific to men, and one was found only in women.
One of the genetic variants was near genes associated with male baldness, suggesting a tie to sex hormones such as testosterone, and another was in an area rich in smell genes, which have been linked to sexual attraction. When the researchers combined all the variants they measured across the entire genome, they estimate that genetics can explain between 8% and 25% of nonheterosexual behavior. The rest, they say, is explained by environmental influences, which could range from hormone exposure in the womb to social influences later in life.
Science | AAAS
www.sciencemag.org
The study is located here:
AAAS
science.sciencemag.org
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