I am sure many of the big D-I and D-II teams like St. Xavier, St. Edward, St. Ignatius, Archbishop Moeller, Pickerington Central and North, Colerain, Upper Arlington, Medina, Mentor, Archbishop Hoban, Massillon, Avon, TCC, etc can beat anyone in D-III, but the other posters are talking about relative difficulty, relative to the size of the schools.
Basically what everyone is saying is that the majority of the top teams from D-III were in region 9 this year. The majority of the other divisions have the top teams distributed through all 4 regions. D-III has probably 6 or 7 of the top 10 teams in region 9.