Here are some ideas for matchups (at least on the NEO side)
Week 2:
Riverside/Perry (I believe the two have played in the past, and wouldn't be a far drive for either)
Riverside/Hoban (The Beavers only lost by 21 last season in the playoffs. MAYBE they catch Hoban in a down year?)
Green/Fitch (Same division, different region)
Week 3:
Ursuline/Niles or South Range (Makes a LOT of sense. Wonder why it wouldn't happen though?) If not, they could play Massillon, or even St. Eds (the latter more than likely is about as likely as me being Mr. Football, but stranger things have happened).
BUT, it could be a pretty decent draw if it did happen. If Iggy can make a trip to Mahoning Valley, no reason why Eds can't. Or if Eds wants to host, that wouldn't be bad either.
Ursuline/South Range would be a nice early season matchup. The Raiders have shown they can hang with the big dogs, and this would be no exception.
Week 4:
Fitch/Maple Heights (Two teams that are evenly matched and could meet in the Region 5 postseason)
Iggy/Glenville (The two teams met in the past, and if they could work it out, would be a great area matchup. Maybe this gets played at Byers, John Carroll, or Case?)
St. Ignatius/Austintown Fitch (Would definitely like to see the two schools run it back. Last year's game was a classic and could have gone either way)
Massillon/Eds would be a hot ticket as well. Hopefully the Tigers are willing to make the trip up to Lakewood.
Maybe not super likely, but Glenville/Steubenville?
Week 5:
Hoban/St. Eds
Hoban/Massillon (only possible if one of them moves up a division). If so, this game would be the hottest ticket in town.
Week 7:
Bishop Watterson/University School (Could definitely see this happening, regardless of venue)
Cleveland Heights/Massillon Washington (Also a pretty solid potential matchup)